Organic Synthesis

 The Winne research group

 

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  From L to R: Tengrui Yuan, Bram Ryckaert, Mien Christiaens, Jan Hullaert, Brenda Callebaut, Kâmil Unal, Bram Denoo
and Prof. Dr. Johan Winne

 

Research

The main focus of the organic synthesis research group is the chemical synthesis and derivatisation of organic compounds with non-trivial carbon connectivities, such as those found in polycyclic Natural Products. The design and selection of target structures is guided by a specific interest in reactivity patterns and/or a specific interest in biological phenomena. This research often follows a substrate-driven approach which relies on the use of highly modular synthetic intermediates as versatile building blocks or chemical platforms for various applications.

  1. The chemical synthesis research mainly involves the development of novel strategies and methods to assemble complex polycyclic scaffolds found in Nature, focusing on multiple bond forming steps such as cycloadditions and cascade reactions.[1], [2]
  2. The chemical derivatisation research focuses on the development of application-oriented versatile covalent ligation reactions (such as click-type reactions) to generate multiple functional derivatives from simple substrates or synthetic intermediates.[3]
  3. A major recent theme, which encompasses both of the above general topics, consists of research directed at the design and synthesis of highly modular synthetic building blocks that allow a rapid exploration of Natural Product-like chemical space using simple and orthogonal functional group transformations. [4]
  4. The concepts of versatile ligation/functionalisation reactions and modular building blocks in organic synthesis are also explored and applied in various collaborative research projects ranging from macromolecular and materials science to chemical biology. [5], [6]

 

News

Jun 27, 2017  Our synpacts paper in Synlett is now online.

Dec 12, 2016  Brenda has been awarded the FWO-SB grant!

Dec 1, 2016   Kâmil Ünal joins our group as joint PhD-student (with Prof. Filip Duprez)

Oct 26, 2016  Jan wins a poster prize at the CRF-1 symposium!

Sep 22, 2016  Jan's paper in Angewandte Chemie is now online.

July 6, 2016    Mien wins a poster prize at the ECHC in Amsterdam!

 

Links

Researchgate profile page

Research groups @ Department of Organic and Macromolecular Chemistry

Chemical expertise @ UGent: brochures for industry (consultancy and contract research)

August Kekulé @ UGent

Leo Baekeland @ UGent (dutch site)

Frédéric Swarts @ UGent

Pierre De Clercq @ UGent

Chemistry tree